The Bio-TUNE project is part of the MSCA-RISE Horizon 2020 program funded by the European Union. This project aims to develop multifunctional biomedical scaffolds as an innovative medical implant with instructive potential for cells and antibacterial properties. One of the key aspects of the Bio-TUNE project is its partnership with world-renowned universities, including Universitas Gadjah Mada (UGM), strengthening research and innovation in the biomedical field.
drg. Ivan Arie Wahyudi, M.Kes., PhD., lecturer from the Department of Biomedical Dentistry specializing in dental pharmacology, has joined Prof. Matt Dalby at the Centre for Cellular Microenvironment at The University of Glasgow for a three-month placement. During this period, he is conducting research in the laboratories of Prof. Matthew Dalby and Prof. Manuel Salmeron Sanchez under the supervision of Prof. Matthew Dalby and Prof. Ika Dewi Ana. The placement runs from 1 September to 30 November 2024.
During this placement, Dr. Ivan focuses on the therapeutic applications of 3D scaffolds utilizing bioprinting technology for osteogenic characterization, potentially paving the way for new medical solutions in regenerative bone therapy. He will use CaP scaffolds fabricated with 3D printing technology, activate them with PEA + FN + BMP-2, and conduct investigations and characterizations after coating.
Additionally, Dr. Ivan will carry out a supplementary project involving osteogenic differentiation by seeding MSCs (Mesenchymal Stem Cells) pada scaffold onto fully coated scaffolds (PEA + FN + BMP-2). He will utilize the Alamar Blue assay to measure cell proliferation, perform differentiation studies using qPCR analysis and immunostaining, and analyze calcium deposition.
During this placement, Dr. Ivan focuses on the therapeutic applications of 3D scaffolds utilizing bioprinting technology for osteogenic characterization, potentially paving the way for new medical solutions in regenerative bone therapy. He will use CaP scaffolds fabricated with 3D printing technology, activate them with PEA + FN + BMP-2, and conduct investigations and characterizations after coating.
Dr. Ivan will carry out a supplementary project involving osteogenic differentiation by seeding mesenchymal stem cells (MSCs) onto fully coated scaffolds (PEA + FN + BMP-2). He will utilize the Alamar Blue assay to measure cell proliferation, perform differentiation studies using qPCR analysis and immunostaining, and analyze calcium deposition.
The research collaboration between Universitas Gadjah Mada and The University of Glasgow at the Centre for Cellular Microenvironment (CEMI) is expected to yield significant innovations in regenerative therapy development. This initiative supports Sustainable Development Goal (SDG) 4: Quality Education. By leveraging multifunctional 3D scaffold technology, this research not only accelerates the understanding of osteogenic differentiation but also paves the way for new treatment solutions for both hard and soft tissue diseases, aligning with SDG 3: Good Health and Well-being.
Furthermore, the outcomes of this collaborative research could contribute to the advancement of medical practices, ultimately enhancing the quality of life in society, in line with SDG 9: Industry, Innovation, and Infrastructure. This initiative is also expected to strengthen research collaboration between Indonesia and the United Kingdom, making a significant contribution to the development of science and technology in cellular microenvironments, supporting SDG 17: Partnerships for the Goals.
Authors: Tia & Pram
