{"id":20898,"date":"2026-07-21T11:28:15","date_gmt":"2026-07-21T04:28:15","guid":{"rendered":"https:\/\/fkg.ugm.ac.id\/?p=20898"},"modified":"2026-07-21T11:28:17","modified_gmt":"2026-07-21T04:28:17","slug":"suntikan-kecil-untuk-masalah-besar-mencegah-gigi-kembali-ke-posisi-semula","status":"publish","type":"post","link":"https:\/\/fkg.ugm.ac.id\/en\/suntikan-kecil-untuk-masalah-besar-mencegah-gigi-kembali-ke-posisi-semula\/","title":{"rendered":"A Small Injection for a Major Problem: Preventing Teeth from Returning to Their Original Position"},"content":{"rendered":"<p class=\"wp-block-paragraph translation-block\">Imagine undergoing orthodontic treatment for two to three years, only to find that several months after the appliance is removed, your teeth gradually begin shifting back toward their original positions. This phenomenon is not necessarily a patient\u2019s failure\u2014it is one of the most frustrating challenges in orthodontics, known as relapse. A study from Universitas Gadjah Mada has attempted to address this longstanding problem through an unexpected approach: injecting a combination of bioceramic material and blood plasma directly into the gingival tissue.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>When Bone Has Not Yet Adjusted to the New Position<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Relapse occurs because the alveolar bone\u2014the bone supporting the teeth\u2014has not fully adapted to the teeth\u2019s new positions after orthodontic appliances are removed. Under these circumstances, the body responds in a manner contrary to the desired outcome. RANKL protein levels increase sharply, triggering osteoclast activity that resorbs bone, while OPG (osteoprotegerin), which should inhibit this destructive process, decreases.<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">Published in Key Engineering Materials, the study involved Prof. Dr. drg. Pinandi Sri Pudyani, SU., Sp.Ort(K), from the Department of Orthodontics, FKG UGM, together with Ananto Ali Alhasyimi, Widya Asmara, and Ika Dewi Ana. The team designed a multilayered solution by combining carbonated hydroxyapatite (CHA) in hydrogel form with advanced platelet-rich fibrin (aPRF), which is rich in growth factors.<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">CHA is a bioceramic with a porous structure resembling cancellous bone. This characteristic makes it suitable as a carrier for bioactive substances and as a promoter of bone regeneration. Meanwhile, aPRF is a newer modification of PRF, produced by centrifuging blood at a lower speed for a longer duration, resulting in a much higher platelet concentration. In this study, the platelet concentration in aPRF reached 4.78 times that of whole blood, exceeding levels reported in similar previous studies.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Hydrogel, Centrifugation, and Forty-Five Rabbits<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The CHA hydrogel was produced using bovine bone gelatin and calcium carbonate formulated into three different compositions: 30-CHA, 40-CHA, and 50-CHA. FTIR analysis confirmed the successful formation of carbonated apatite during fabrication. Among the three compositions, 30-CHA demonstrated the most ideal degradation profile\u2014it did not degrade too rapidly, allowing growth factors to be released gradually into the target area.<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">Forty-five New Zealand rabbits were then divided into three groups: a control group without injection, a group receiving CHA alone, and a CHA-aPRF group. The rabbits\u2019 lower incisors were orthodontically moved using a nickel-titanium open-coil spring for one week, retained for two weeks, and then allowed to relapse for 21 days. During the retention period, the hydrogel was injected into the mesial gingival sulcus every seven days.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>\u201cThe results of this study demonstrate that the incorporation of CHA hydrogel has the potential to enhance alveolar bone remodeling and prevent orthodontic relapse by stimulating OPG expression and suppressing RANKL expression.\u201d<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">The numerical findings were equally clear. On day 21 after appliance removal, the CHA-aPRF group recorded the lowest percentage of relapse, at only 29.95%, compared with a substantially higher percentage in the control group. RANKL expression in this group was significantly the lowest on days 0, 3, and 7, while OPG expression was highest on days 14 and 21.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>When the Patient\u2019s Own Blood Becomes the Treatment<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">What makes this approach particularly interesting is not only its results but also its underlying mechanism. aPRF is derived from the rabbits\u2019 own blood\u2014making it autologous\u2014and therefore does not require additional materials such as bovine thrombin or calcium chloride, which have been limitations of earlier generations of PRP. Because no external anticoagulants are used, the risk of antibody formation that could lead to coagulopathy is also avoided.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PRF has also been shown to release growth factors gradually over a longer period than PRP. Within the CHA hydrogel system, this release becomes even more controlled: growth factors are not released all at once but instead act gradually at the required site. Increased OPG binds to RANKL and blocks its interaction with RANK, thereby inhibiting osteoclast differentiation and slowing bone resorption.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bagi dunia ortodonsia, implikasi penelitian ini cukup signifikan. Retensi pasca perawatan selama ini sangat bergantung pada pemakaian <em>retainer<\/em> oleh pasien \u2014 yang notabene tidak selalu konsisten. Jika injeksi lokal CHA-aPRF suatu hari dapat diintegrasikan ke dalam protokol klinis, maka stabilitas hasil perawatan tidak lagi sepenuhnya bergantung pada kepatuhan pasien memakai alat.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tentu masih ada jarak antara model hewan dan aplikasi klinis pada manusia. Namun langkah pertama itu sudah diambil \u2014 dengan suntikan kecil, dan pertanyaan yang jawabannya terus dicari.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Source DOI: <a href=\"http:\/\/10.4028\/www.scientific.net\/KEM.758.255\">http:\/\/10.4028\/www.scientific.net\/KEM.758.255<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Authors: Nanda Ayu; drg. Achmad Zam Zam Aghasy, M.Kes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Photo: Pexels<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Bayangkan menjalani perawatan kawat gigi selama dua hingga tiga tahun, lalu beberapa bulan setelah alat dilepas, gigi perlahan-lahan bergerak kembali ke posisi awal. Fenomena ini bukan kegagalan pasien \u2014 ini adalah salah satu tantangan paling frustrasi dalam ortodonsia, yang dikenal sebagai relapse. Sebuah penelitian dari Universitas Gadjah Mada mencoba menjawab pertanyaan lama itu dengan pendekatan [&hellip;]<\/p>\n","protected":false},"author":615,"featured_media":20900,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[359,136,326,318,316,317,321],"tags":[298,307,289,291,297],"class_list":["post-20898","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artikel","category-berita-terbaru","category-sdg-10","category-sdg-17","category-sdg-3","category-sdg-4","category-sdg-9","tag-sdg-10-mengurangi-ketidaksetaraan","tag-sdg-17-kemitraan-untuk-mencapai-tujuan","tag-sdg-3-kesehatan-dan-kesejahteraan-yang-baik","tag-sdg-4-pendidikan-berkualitas","tag-sdg-9-industri-inovasi-dan-infrastruktur"],"gutentor_comment":0,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Suntikan Kecil untuk Masalah Besar: Mencegah Gigi Kembali ke Posisi Semula - Fakultas Kedokteran Gigi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fkg.ugm.ac.id\/en\/suntikan-kecil-untuk-masalah-besar-mencegah-gigi-kembali-ke-posisi-semula\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Suntikan Kecil untuk Masalah Besar: Mencegah Gigi Kembali ke Posisi Semula - Fakultas Kedokteran Gigi\" \/>\n<meta property=\"og:description\" content=\"Bayangkan menjalani perawatan kawat gigi selama dua hingga tiga tahun, lalu beberapa bulan setelah alat dilepas, gigi perlahan-lahan bergerak kembali ke posisi awal. Fenomena ini bukan kegagalan pasien \u2014 ini adalah salah satu tantangan paling frustrasi dalam ortodonsia, yang dikenal sebagai relapse. Sebuah penelitian dari Universitas Gadjah Mada mencoba menjawab pertanyaan lama itu dengan pendekatan [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fkg.ugm.ac.id\/en\/suntikan-kecil-untuk-masalah-besar-mencegah-gigi-kembali-ke-posisi-semula\/\" \/>\n<meta property=\"og:site_name\" content=\"Fakultas Kedokteran Gigi\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/p\/Fakultas-Kedokteran-Gigi-UGM-100075927681679\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-07-21T04:28:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-21T04:28:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/fkg.ugm.ac.id\/wp-content\/uploads\/sites\/30\/2026\/07\/pexels-mikhail-nilov-7469473-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1269\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"achmadzamzamaghasy\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"achmadzamzamaghasy\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/suntikan-kecil-untuk-masalah-besar-mencegah-gigi-kembali-ke-posisi-semula\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/suntikan-kecil-untuk-masalah-besar-mencegah-gigi-kembali-ke-posisi-semula\\\/\"},\"author\":{\"name\":\"achmadzamzamaghasy\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/#\\\/schema\\\/person\\\/5e527b2939dff262f173d10f32d2638a\"},\"headline\":\"Suntikan Kecil untuk Masalah Besar: Mencegah Gigi Kembali ke Posisi Semula\",\"datePublished\":\"2026-07-21T04:28:15+00:00\",\"dateModified\":\"2026-07-21T04:28:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/suntikan-kecil-untuk-masalah-besar-mencegah-gigi-kembali-ke-posisi-semula\\\/\"},\"wordCount\":669,\"publisher\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/suntikan-kecil-untuk-masalah-besar-mencegah-gigi-kembali-ke-posisi-semula\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/wp-content\\\/uploads\\\/sites\\\/30\\\/2026\\\/07\\\/pexels-mikhail-nilov-7469473-scaled.jpg\",\"keywords\":[\"SDG 10: Mengurangi Ketidaksetaraan\",\"SDG 17: Kemitraan untuk mencapai Tujuan\",\"SDG 3: Kesehatan dan Kesejahteraan yang Baik\",\"SDG 4: Pendidikan Berkualitas\",\"SDG 9: Industri, Inovasi dan Infrastruktur\"],\"articleSection\":[\"Artikel\",\"Berita Terbaru\",\"SDG 10\",\"SDG 17\",\"SDG 3\",\"SDG 4\",\"SDG 9\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/suntikan-kecil-untuk-masalah-besar-mencegah-gigi-kembali-ke-posisi-semula\\\/\",\"url\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/suntikan-kecil-untuk-masalah-besar-mencegah-gigi-kembali-ke-posisi-semula\\\/\",\"name\":\"Suntikan Kecil untuk Masalah Besar: Mencegah Gigi Kembali ke Posisi Semula - 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Fenomena ini bukan kegagalan pasien \u2014 ini adalah salah satu tantangan paling frustrasi dalam ortodonsia, yang dikenal sebagai relapse. 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