{"id":20689,"date":"2026-07-17T14:05:52","date_gmt":"2026-07-17T07:05:52","guid":{"rendered":"https:\/\/fkg.ugm.ac.id\/?p=20689"},"modified":"2026-07-17T14:05:54","modified_gmt":"2026-07-17T07:05:54","slug":"bawang-putih-di-laboratorium-saat-herbal-dapur-terbukti-ramah-bagi-sel-gusi","status":"publish","type":"post","link":"https:\/\/fkg.ugm.ac.id\/en\/bawang-putih-di-laboratorium-saat-herbal-dapur-terbukti-ramah-bagi-sel-gusi\/","title":{"rendered":"Garlic in the Laboratory: When a Common Kitchen Herb Proves Friendly to Gingival Cells"},"content":{"rendered":"<p class=\"wp-block-paragraph translation-block\">The figure is surprising: 145.46%. This is neither a stock-market return nor an exam score exceeding the scale. It represents the viability of human gingival fibroblast cells after exposure to garlic extract for 48 hours. In other words, the gingival tissue cells studied not only survived but proliferated more actively than the control group. This finding came from research published in the Bangladesh Journal of Medical Science (Vol. 17, No. 4, October 2018), led by Dr. drg. Indra Bramanti, M.Sc., Sp.KGA(K), who at the time was enrolled in the postgraduate program at the Faculty of Dentistry, Universitas Gadjah Mada.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>From the Kitchen to Cell Culture<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">Garlic (Allium sativum L.) is a familiar ingredient on Indonesian dining tables. Yet behind its strong aroma are active compounds that have long attracted medical interest: allicin, flavonoids, and diallyl disulfide. All three are known to possess antibacterial and anti-inflammatory properties. What had not been extensively explored was whether garlic extract is safe for human cells, particularly cells involved in oral tissue healing.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The research arose from a real clinical problem. Extensive caries in primary teeth can lead to pulp exposure and necrosis, conditions that require root canal treatment in children. Commonly used root canal dressing materials, such as calcium hydroxide and Cresophene, still require thorough evaluation regarding their effects on periapical tissues. Garlic extract was proposed as a potential alternative, provided that it was biocompatible and did not damage the cells surrounding dental tissues.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Viability Testing: Twelve Concentrations, Three Time Points<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The researchers prepared human gingival fibroblasts obtained from gingival tissue collected from patients undergoing tooth extraction for orthodontic treatment. The cells were cultured under controlled laboratory conditions and exposed to fourteen serial concentrations of ethanolic garlic extract, ranging from 0.3125 to 2,560 \u03bcg\/mL. Observations were made at 24, 48, and 72 hours using the MTT assay, a standard method for measuring cell viability and proliferation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The results were consistent across the treatment groups: all concentrations of garlic extract increased gingival fibroblast viability and proliferation. The highest viability was recorded at a concentration of 1.25 \u03bcg\/mL after 48 hours, reaching 145.46%. Even at the lowest concentration of 0.3125 \u03bcg\/mL, cell viability remained above 100%. The only value that fell slightly below the 100% threshold was recorded at a concentration of 0.625 \u03bcg\/mL after 72 hours, at 79.9%, which was still well above the toxicity threshold.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><em>\u201cThe ethanolic garlic extract has a good biocompatibility to human gingival fibroblasts culture cell and can stimulate cell growth that is seen from the proliferation of human gingival fibroblasts cell.\u201d \u2014 Bramanti et al., Bangladesh Journal of Medical Science, 2018<\/em><\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The Mechanism Behind the Numbers<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Why would garlic actually promote cell growth? The answer may lie in the synergistic effects of its active compounds. Allicin acts as an anti-inflammatory agent by suppressing spontaneous TNF-\u03b1 production, inhibiting NF-\u03baB activation, and stimulating the production of IL-10, which helps suppress inflammatory responses. During the tissue repair phase, this creates an environment conducive to fibroblast proliferation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Meanwhile, flavonoids in garlic stimulate the production of TGF-\u03b2, a growth factor that promotes fibroblast migration and proliferation into wound areas. Flavonoids also induce VEGF, which plays a role in new blood vessel formation. The third compound, diallyl disulfide, helps break down proteins in damaged cells and enhances phagocytic activity, strengthening the cellular immune response.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Statistical analysis using the Kruskal-Wallis and Mann-Whitney U tests showed no significant differences in viability among concentration groups at each observation point (p&gt;0.05). However, significant differences were observed between observation time points (p&lt;0.05), particularly between 24 and 48 hours and between 48 and 72 hours. This pattern is consistent with the cell growth cycle as it approaches the stationary phase around 72 hours.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Implications for Pediatric Dentistry<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">This study opens a door that had previously been only partially open. One of the primary concerns regarding the use of herbal materials in clinical procedures is their potential toxicity to biological tissues. The findings from this study address that concern, at least at the level of in vitro cell culture: ethanolic garlic extract was not only safe but also actively supported gingival fibroblast growth.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The concentration of 1.25 \u03bcg\/mL, which produced the highest viability, was even suggested as a potential candidate for use as a root canal dressing material for primary teeth. This is certainly not a definitive clinical conclusion; further in vivo studies and clinical trials are still required. Nevertheless, for pediatric dentistry, which continues to seek more natural, affordable, and minimally harmful treatment materials, garlic may now be more than just a culinary ingredient.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It is also worth noting that the garlic used in the study was obtained from the Tawangmangu Medicinal Plant Center in Central Java. From the slopes of the mountains to a cell-culture dish in the Pharmacology Laboratory of the Faculty of Medicine, UGM, this humble plant appears to hold potential that we do not yet fully understand.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Source DOI: <a href=\"http:\/\/dx.doi.org\/10.3329\/bjms.v17i4.38315\">http:\/\/dx.doi.org\/10.3329\/bjms.v17i4.38315<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Authors: Nanda Ayu, drg. Achmad Zam Zam Aghasy, M.Kes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Photo: Pexels <\/p>","protected":false},"excerpt":{"rendered":"<p>Angka itu terasa mengejutkan: 145,46 persen. Bukan persentase keuntungan saham, bukan pula skor ujian yang melampaui skala. Itu adalah tingkat viabilitas sel fibroblas gingiva manusia setelah dipapar ekstrak bawang putih selama 48 jam. Artinya, sel-sel jaringan gusi yang diteliti tidak hanya bertahan hidup, tapi justru berkembang biak lebih aktif dibandingkan kelompok kontrol. Temuan ini lahir [&hellip;]<\/p>\n","protected":false},"author":615,"featured_media":20690,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[359,136,326,322,329,316,317,321],"tags":[298,302,305,289,291,297],"class_list":["post-20689","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artikel","category-berita-terbaru","category-sdg-10","category-sdg-12","category-sdg-15","category-sdg-3","category-sdg-4","category-sdg-9","tag-sdg-10-mengurangi-ketidaksetaraan","tag-sdg-12-konsumsi-dan-produksi-yang-bertanggung-jawab","tag-sdg-15-kehidupan-di-darat","tag-sdg-3-kesehatan-dan-kesejahteraan-yang-baik","tag-sdg-4-pendidikan-berkualitas","tag-sdg-9-industri-inovasi-dan-infrastruktur"],"gutentor_comment":0,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Bawang Putih di Laboratorium: Saat Herbal Dapur Terbukti Ramah bagi Sel Gusi - Fakultas Kedokteran Gigi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fkg.ugm.ac.id\/en\/bawang-putih-di-laboratorium-saat-herbal-dapur-terbukti-ramah-bagi-sel-gusi\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bawang Putih di Laboratorium: Saat Herbal Dapur Terbukti Ramah bagi Sel Gusi - Fakultas Kedokteran Gigi\" \/>\n<meta property=\"og:description\" content=\"Angka itu terasa mengejutkan: 145,46 persen. Bukan persentase keuntungan saham, bukan pula skor ujian yang melampaui skala. Itu adalah tingkat viabilitas sel fibroblas gingiva manusia setelah dipapar ekstrak bawang putih selama 48 jam. Artinya, sel-sel jaringan gusi yang diteliti tidak hanya bertahan hidup, tapi justru berkembang biak lebih aktif dibandingkan kelompok kontrol. Temuan ini lahir [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fkg.ugm.ac.id\/en\/bawang-putih-di-laboratorium-saat-herbal-dapur-terbukti-ramah-bagi-sel-gusi\/\" \/>\n<meta property=\"og:site_name\" content=\"Fakultas Kedokteran Gigi\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/p\/Fakultas-Kedokteran-Gigi-UGM-100075927681679\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-07-17T07:05:52+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-17T07:05:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/fkg.ugm.ac.id\/wp-content\/uploads\/sites\/30\/2026\/07\/pexels-picasjoe-11348101-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1707\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"achmadzamzamaghasy\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"achmadzamzamaghasy\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/bawang-putih-di-laboratorium-saat-herbal-dapur-terbukti-ramah-bagi-sel-gusi\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/bawang-putih-di-laboratorium-saat-herbal-dapur-terbukti-ramah-bagi-sel-gusi\\\/\"},\"author\":{\"name\":\"achmadzamzamaghasy\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/#\\\/schema\\\/person\\\/5e527b2939dff262f173d10f32d2638a\"},\"headline\":\"Bawang Putih di Laboratorium: Saat Herbal Dapur Terbukti Ramah bagi Sel Gusi\",\"datePublished\":\"2026-07-17T07:05:52+00:00\",\"dateModified\":\"2026-07-17T07:05:54+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/bawang-putih-di-laboratorium-saat-herbal-dapur-terbukti-ramah-bagi-sel-gusi\\\/\"},\"wordCount\":760,\"publisher\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/bawang-putih-di-laboratorium-saat-herbal-dapur-terbukti-ramah-bagi-sel-gusi\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/wp-content\\\/uploads\\\/sites\\\/30\\\/2026\\\/07\\\/pexels-picasjoe-11348101-scaled.jpg\",\"keywords\":[\"SDG 10: Mengurangi Ketidaksetaraan\",\"SDG 12: Konsumsi dan Produksi yang Bertanggung Jawab\",\"SDG 15: Kehidupan di Darat\",\"SDG 3: Kesehatan dan Kesejahteraan yang Baik\",\"SDG 4: Pendidikan Berkualitas\",\"SDG 9: Industri, Inovasi dan Infrastruktur\"],\"articleSection\":[\"Artikel\",\"Berita Terbaru\",\"SDG 10\",\"SDG 12\",\"SDG 15\",\"SDG 3\",\"SDG 4\",\"SDG 9\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/bawang-putih-di-laboratorium-saat-herbal-dapur-terbukti-ramah-bagi-sel-gusi\\\/\",\"url\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/bawang-putih-di-laboratorium-saat-herbal-dapur-terbukti-ramah-bagi-sel-gusi\\\/\",\"name\":\"Bawang Putih di Laboratorium: Saat Herbal Dapur Terbukti Ramah bagi Sel Gusi - 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Bukan persentase keuntungan saham, bukan pula skor ujian yang melampaui skala. Itu adalah tingkat viabilitas sel fibroblas gingiva manusia setelah dipapar ekstrak bawang putih selama 48 jam. Artinya, sel-sel jaringan gusi yang diteliti tidak hanya bertahan hidup, tapi justru berkembang biak lebih aktif dibandingkan kelompok kontrol. 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