{"id":20654,"date":"2026-07-17T12:30:19","date_gmt":"2026-07-17T05:30:19","guid":{"rendered":"https:\/\/fkg.ugm.ac.id\/?p=20654"},"modified":"2026-07-17T12:30:21","modified_gmt":"2026-07-17T05:30:21","slug":"kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin","status":"publish","type":"post","link":"https:\/\/fkg.ugm.ac.id\/en\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/","title":{"rendered":"The Hidden Key to Tooth Formation: The Irx3 Gene and the Secret Behind Dentin"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>Imagine a tooth that fails to develop properly not because of bacteria or trauma, but because a single gene stops functioning. This is the question that prompted drg. Anrizandy Narwidina, MDSc, Sp.KGA, Ph.D., and a team of researchers from several institutions in Japan to explore one of the most fundamental layers of tooth development: the molecular mechanisms that control dentin-forming cells.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">Their findings, published in Biochemical and Biophysical Research Communications in February 2023, revealed something that had not previously been reported. A gene called Iroquois homeobox 3, or Irx3, previously known primarily for its roles in the nervous and cardiovascular systems, appears to be a critical determinant of the proliferation and differentiation of odontoblasts\u2014the mesenchymal cells responsible for producing dentin, the major hard component of teeth.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>One Gene, Two Different Cellular Worlds<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">The study began with a simple question: of the six members of the Irx gene family (Irx1 to Irx6), which ones are active in dental tissue? The team extracted dental tissue from postnatal day 1 (P1) mice and analysed mRNA expression using RT-PCR. The results showed that five of the six genes\u2014Irx1, Irx2, Irx3, Irx5, and Irx6\u2014were detected in dental tissue, while Irx4 was not.<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">What was interesting was not simply the presence of these genes but their distribution patterns. When the analysis was narrowed to two odontogenic cell lines\u2014the dental epithelial M3H1 cells and dental mesenchymal mDP cells\u2014only Irx3 was expressed in both. M3H1 cells contained Irx1, Irx2, and Irx3, whereas mDP cells contained only Irx3 and Irx5. The only gene present in both epithelial and mesenchymal compartments was Irx3.<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">Visual confirmation through immunostaining of E13.5-stage tooth embryos reinforced the finding: IRX3 protein was detected in both dental epithelial cells and the dental mesenchymal condensation area. This strategic position strongly suggests that Irx3 plays a role at the intersection of two cellular worlds that communicate with each other during odontogenesis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>When the Gene Is Silenced, Cells Stop Developing<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">To establish the function of Irx3, the researchers used siRNA-mediated knockdown, a technique that selectively suppresses the expression of a target gene. When Irx3 was silenced in mDP cells, the effects were dramatic. Cell numbers decreased significantly during the first 24\u201348 hours, indicating impaired proliferation. Furthermore, the cells' ability to differentiate into odontoblasts was also compromised: the formation of mineralised nodules, assessed using Alizarin Red S staining, declined sharply compared with control cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>\u201cThese results indicate that Irx3 plays an important role, at least in part, through regulation of Wnt5a expression during odontoblast proliferation and differentiation.\u201d \u2014 Anrizandy Narwidina and colleagues, Biochemical and Biophysical Research Communications, 2023<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">Experiments using three different siRNA sequences, designed to minimise off-target effects, produced similar results: without Irx3, mineralisation of mDP cells was disrupted.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Irx3 Works Through Wnt5a<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">The next question was how Irx3 performs its function. The researchers evaluated the expression of various growth factors known to be involved in odontoblast differentiation, including several members of the Wnt and Bmp families. Quantitative PCR analysis identified three molecules that were strongly expressed in mDP cells: Wnt3a, Wnt5a, and Bmp4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">However, when Irx3 was silenced, only Wnt5a was significantly suppressed. The expression of Wnt3a and Bmp4 was unaffected. This finding suggests that the role of Irx3 in odontogenesis is specific: it regulates the differentiation of dental mesenchymal cells, at least in part, by controlling Wnt5a expression\u2014a molecule previously known to contribute to the formation of mineralised nodules and the induction of mineralisation-related genes such as dentine matrix protein-1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">The relationship between Irx3 and Wnt5a did not emerge unexpectedly. In the kidneys, Irx3 interacts with Wnt5a during tubular maturation. In Wilms tumour models, cells deficient in Irx3 show reduced WNT5A expression. The same pattern has now been confirmed in dental tissue, strengthening the hypothesis that the Irx3\u2013Wnt5a relationship represents a regulatory axis conserved across different tissues.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>From the Laboratory to Understanding Dental Anomalies<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">This discovery is more than a molecular biology achievement. Understanding how Irx3 regulates odontoblast proliferation and differentiation opens a new window into developmental dental anomalies whose underlying mechanisms have remained unclear. Mutations in genes belonging to the Irx family have previously been associated with Hamamy syndrome, a rare genetic disorder involving hypodontia and craniofacial dysmorphism.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study by drg. Anrizandy Narwidina and colleagues fills an important knowledge gap: how dental papilla cells receive the \u201cinstructions\u201d to proliferate, differentiate, and ultimately form dentin that serves as the structural backbone of the tooth. The answer, at least in part, lies in a single gene working quietly at the intersection of two cellular worlds\u2014and it is no longer hidden.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Source DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.bbrc.2023.02.004\">https:\/\/doi.org\/10.1016\/j.bbrc.2023.02.004<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Authors: Nanda Ayu, drg. Achmad Zam Zam Aghasy, M.Kes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Photo: Pexels<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Bayangkan sebuah gigi yang gagal terbentuk sempurna bukan karena kuman, bukan karena trauma, melainkan karena satu gen yang berhenti bekerja. Itulah pertanyaan yang mendorong drg. Anrizandy Narwidina, MDSc, Sp.KGA, Ph.D, bersama tim peneliti lintas institusi di Jepang untuk menyelami lapisan paling fundamental dari perkembangan gigi: mekanisme molekuler yang mengendalikan sel-sel pembentuk dentin. Hasilnya, yang dipublikasikan [&hellip;]<\/p>\n","protected":false},"author":615,"featured_media":20655,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[359,136,326,318,316,317,321],"tags":[298,307,289,291,297],"class_list":["post-20654","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artikel","category-berita-terbaru","category-sdg-10","category-sdg-17","category-sdg-3","category-sdg-4","category-sdg-9","tag-sdg-10-mengurangi-ketidaksetaraan","tag-sdg-17-kemitraan-untuk-mencapai-tujuan","tag-sdg-3-kesehatan-dan-kesejahteraan-yang-baik","tag-sdg-4-pendidikan-berkualitas","tag-sdg-9-industri-inovasi-dan-infrastruktur"],"gutentor_comment":0,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Kunci Tersembunyi Pembentukan Gigi: Gen Irx3 dan Rahasia di Balik Dentin - Fakultas Kedokteran Gigi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fkg.ugm.ac.id\/en\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kunci Tersembunyi Pembentukan Gigi: Gen Irx3 dan Rahasia di Balik Dentin - Fakultas Kedokteran Gigi\" \/>\n<meta property=\"og:description\" content=\"Bayangkan sebuah gigi yang gagal terbentuk sempurna bukan karena kuman, bukan karena trauma, melainkan karena satu gen yang berhenti bekerja. Itulah pertanyaan yang mendorong drg. Anrizandy Narwidina, MDSc, Sp.KGA, Ph.D, bersama tim peneliti lintas institusi di Jepang untuk menyelami lapisan paling fundamental dari perkembangan gigi: mekanisme molekuler yang mengendalikan sel-sel pembentuk dentin. Hasilnya, yang dipublikasikan [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fkg.ugm.ac.id\/en\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/\" \/>\n<meta property=\"og:site_name\" content=\"Fakultas Kedokteran Gigi\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/p\/Fakultas-Kedokteran-Gigi-UGM-100075927681679\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-07-17T05:30:19+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-17T05:30:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/fkg.ugm.ac.id\/wp-content\/uploads\/sites\/30\/2026\/07\/pexels-cottonbro-6528854-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1465\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"achmadzamzamaghasy\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"achmadzamzamaghasy\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\\\/\"},\"author\":{\"name\":\"achmadzamzamaghasy\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/#\\\/schema\\\/person\\\/5e527b2939dff262f173d10f32d2638a\"},\"headline\":\"Kunci Tersembunyi Pembentukan Gigi: Gen Irx3 dan Rahasia di Balik Dentin\",\"datePublished\":\"2026-07-17T05:30:19+00:00\",\"dateModified\":\"2026-07-17T05:30:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\\\/\"},\"wordCount\":715,\"publisher\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/wp-content\\\/uploads\\\/sites\\\/30\\\/2026\\\/07\\\/pexels-cottonbro-6528854-scaled.jpg\",\"keywords\":[\"SDG 10: Mengurangi Ketidaksetaraan\",\"SDG 17: Kemitraan untuk mencapai Tujuan\",\"SDG 3: Kesehatan dan Kesejahteraan yang Baik\",\"SDG 4: Pendidikan Berkualitas\",\"SDG 9: Industri, Inovasi dan Infrastruktur\"],\"articleSection\":[\"Artikel\",\"Berita Terbaru\",\"SDG 10\",\"SDG 17\",\"SDG 3\",\"SDG 4\",\"SDG 9\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\\\/\",\"url\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\\\/\",\"name\":\"Kunci Tersembunyi Pembentukan Gigi: Gen Irx3 dan Rahasia di Balik Dentin - Fakultas Kedokteran Gigi\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/wp-content\\\/uploads\\\/sites\\\/30\\\/2026\\\/07\\\/pexels-cottonbro-6528854-scaled.jpg\",\"datePublished\":\"2026-07-17T05:30:19+00:00\",\"dateModified\":\"2026-07-17T05:30:21+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/fkg.ugm.ac.id\\\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\\\/#primaryimage\",\"url\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/wp-content\\\/uploads\\\/sites\\\/30\\\/2026\\\/07\\\/pexels-cottonbro-6528854-scaled.jpg\",\"contentUrl\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/wp-content\\\/uploads\\\/sites\\\/30\\\/2026\\\/07\\\/pexels-cottonbro-6528854-scaled.jpg\",\"width\":2560,\"height\":1465},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Kunci Tersembunyi Pembentukan Gigi: Gen Irx3 dan Rahasia di Balik Dentin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/#website\",\"url\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/\",\"name\":\"Fakultas Kedokteran Gigi\",\"description\":\"Universitas Gadjah Mada\",\"publisher\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/#organization\",\"name\":\"Fakultas Kedokteran Gigi\",\"url\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/wp-content\\\/uploads\\\/sites\\\/30\\\/2024\\\/05\\\/Group.png\",\"contentUrl\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/wp-content\\\/uploads\\\/sites\\\/30\\\/2024\\\/05\\\/Group.png\",\"width\":248,\"height\":257,\"caption\":\"Fakultas Kedokteran Gigi\"},\"image\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/p\\\/Fakultas-Kedokteran-Gigi-UGM-100075927681679\\\/\",\"https:\\\/\\\/www.instagram.com\\\/fkgugm\\\/?igshid=MTNiYzNiMzkwZA\",\"https:\\\/\\\/www.youtube.com\\\/@ugmfkg2266\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/#\\\/schema\\\/person\\\/5e527b2939dff262f173d10f32d2638a\",\"name\":\"achmadzamzamaghasy\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/703457fd59defa6504a99ae1c5e493d7e564bb3bac4c47b8ce9215cbfb298e36?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/703457fd59defa6504a99ae1c5e493d7e564bb3bac4c47b8ce9215cbfb298e36?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/703457fd59defa6504a99ae1c5e493d7e564bb3bac4c47b8ce9215cbfb298e36?s=96&d=mm&r=g\",\"caption\":\"achmadzamzamaghasy\"},\"url\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/en\\\/author\\\/achmadzamzamaghasy\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Kunci Tersembunyi Pembentukan Gigi: Gen Irx3 dan Rahasia di Balik Dentin - Fakultas Kedokteran Gigi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fkg.ugm.ac.id\/en\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/","og_locale":"en_US","og_type":"article","og_title":"Kunci Tersembunyi Pembentukan Gigi: Gen Irx3 dan Rahasia di Balik Dentin - Fakultas Kedokteran Gigi","og_description":"Bayangkan sebuah gigi yang gagal terbentuk sempurna bukan karena kuman, bukan karena trauma, melainkan karena satu gen yang berhenti bekerja. Itulah pertanyaan yang mendorong drg. Anrizandy Narwidina, MDSc, Sp.KGA, Ph.D, bersama tim peneliti lintas institusi di Jepang untuk menyelami lapisan paling fundamental dari perkembangan gigi: mekanisme molekuler yang mengendalikan sel-sel pembentuk dentin. Hasilnya, yang dipublikasikan [&hellip;]","og_url":"https:\/\/fkg.ugm.ac.id\/en\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/","og_site_name":"Fakultas Kedokteran Gigi","article_publisher":"https:\/\/www.facebook.com\/p\/Fakultas-Kedokteran-Gigi-UGM-100075927681679\/","article_published_time":"2026-07-17T05:30:19+00:00","article_modified_time":"2026-07-17T05:30:21+00:00","og_image":[{"width":2560,"height":1465,"url":"https:\/\/fkg.ugm.ac.id\/wp-content\/uploads\/sites\/30\/2026\/07\/pexels-cottonbro-6528854-scaled.jpg","type":"image\/jpeg"}],"author":"achmadzamzamaghasy","twitter_card":"summary_large_image","twitter_misc":{"Written by":"achmadzamzamaghasy","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/fkg.ugm.ac.id\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/#article","isPartOf":{"@id":"https:\/\/fkg.ugm.ac.id\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/"},"author":{"name":"achmadzamzamaghasy","@id":"https:\/\/fkg.ugm.ac.id\/id\/#\/schema\/person\/5e527b2939dff262f173d10f32d2638a"},"headline":"Kunci Tersembunyi Pembentukan Gigi: Gen Irx3 dan Rahasia di Balik Dentin","datePublished":"2026-07-17T05:30:19+00:00","dateModified":"2026-07-17T05:30:21+00:00","mainEntityOfPage":{"@id":"https:\/\/fkg.ugm.ac.id\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/"},"wordCount":715,"publisher":{"@id":"https:\/\/fkg.ugm.ac.id\/id\/#organization"},"image":{"@id":"https:\/\/fkg.ugm.ac.id\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/#primaryimage"},"thumbnailUrl":"https:\/\/fkg.ugm.ac.id\/wp-content\/uploads\/sites\/30\/2026\/07\/pexels-cottonbro-6528854-scaled.jpg","keywords":["SDG 10: Mengurangi Ketidaksetaraan","SDG 17: Kemitraan untuk mencapai Tujuan","SDG 3: Kesehatan dan Kesejahteraan yang Baik","SDG 4: Pendidikan Berkualitas","SDG 9: Industri, Inovasi dan Infrastruktur"],"articleSection":["Artikel","Berita Terbaru","SDG 10","SDG 17","SDG 3","SDG 4","SDG 9"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/fkg.ugm.ac.id\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/","url":"https:\/\/fkg.ugm.ac.id\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/","name":"Kunci Tersembunyi Pembentukan Gigi: Gen Irx3 dan Rahasia di Balik Dentin - Fakultas Kedokteran Gigi","isPartOf":{"@id":"https:\/\/fkg.ugm.ac.id\/id\/#website"},"primaryImageOfPage":{"@id":"https:\/\/fkg.ugm.ac.id\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/#primaryimage"},"image":{"@id":"https:\/\/fkg.ugm.ac.id\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/#primaryimage"},"thumbnailUrl":"https:\/\/fkg.ugm.ac.id\/wp-content\/uploads\/sites\/30\/2026\/07\/pexels-cottonbro-6528854-scaled.jpg","datePublished":"2026-07-17T05:30:19+00:00","dateModified":"2026-07-17T05:30:21+00:00","breadcrumb":{"@id":"https:\/\/fkg.ugm.ac.id\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fkg.ugm.ac.id\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/fkg.ugm.ac.id\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/#primaryimage","url":"https:\/\/fkg.ugm.ac.id\/wp-content\/uploads\/sites\/30\/2026\/07\/pexels-cottonbro-6528854-scaled.jpg","contentUrl":"https:\/\/fkg.ugm.ac.id\/wp-content\/uploads\/sites\/30\/2026\/07\/pexels-cottonbro-6528854-scaled.jpg","width":2560,"height":1465},{"@type":"BreadcrumbList","@id":"https:\/\/fkg.ugm.ac.id\/kunci-tersembunyi-pembentukan-gigi-gen-irx3-dan-rahasia-di-balik-dentin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/fkg.ugm.ac.id\/"},{"@type":"ListItem","position":2,"name":"Kunci Tersembunyi Pembentukan Gigi: Gen Irx3 dan Rahasia di Balik Dentin"}]},{"@type":"WebSite","@id":"https:\/\/fkg.ugm.ac.id\/id\/#website","url":"https:\/\/fkg.ugm.ac.id\/id\/","name":"Faculty of Dentistry","description":"Universitas Gadjah Mada","publisher":{"@id":"https:\/\/fkg.ugm.ac.id\/id\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fkg.ugm.ac.id\/id\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/fkg.ugm.ac.id\/id\/#organization","name":"Faculty of Dentistry","url":"https:\/\/fkg.ugm.ac.id\/id\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/fkg.ugm.ac.id\/id\/#\/schema\/logo\/image\/","url":"https:\/\/fkg.ugm.ac.id\/wp-content\/uploads\/sites\/30\/2024\/05\/Group.png","contentUrl":"https:\/\/fkg.ugm.ac.id\/wp-content\/uploads\/sites\/30\/2024\/05\/Group.png","width":248,"height":257,"caption":"Fakultas Kedokteran Gigi"},"image":{"@id":"https:\/\/fkg.ugm.ac.id\/id\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/p\/Fakultas-Kedokteran-Gigi-UGM-100075927681679\/","https:\/\/www.instagram.com\/fkgugm\/?igshid=MTNiYzNiMzkwZA","https:\/\/www.youtube.com\/@ugmfkg2266"]},{"@type":"Person","@id":"https:\/\/fkg.ugm.ac.id\/id\/#\/schema\/person\/5e527b2939dff262f173d10f32d2638a","name":"achmadzamzamaghasy","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/703457fd59defa6504a99ae1c5e493d7e564bb3bac4c47b8ce9215cbfb298e36?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/703457fd59defa6504a99ae1c5e493d7e564bb3bac4c47b8ce9215cbfb298e36?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/703457fd59defa6504a99ae1c5e493d7e564bb3bac4c47b8ce9215cbfb298e36?s=96&d=mm&r=g","caption":"achmadzamzamaghasy"},"url":"https:\/\/fkg.ugm.ac.id\/en\/author\/achmadzamzamaghasy\/"}]}},"_links":{"self":[{"href":"https:\/\/fkg.ugm.ac.id\/en\/wp-json\/wp\/v2\/posts\/20654","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fkg.ugm.ac.id\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fkg.ugm.ac.id\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fkg.ugm.ac.id\/en\/wp-json\/wp\/v2\/users\/615"}],"replies":[{"embeddable":true,"href":"https:\/\/fkg.ugm.ac.id\/en\/wp-json\/wp\/v2\/comments?post=20654"}],"version-history":[{"count":1,"href":"https:\/\/fkg.ugm.ac.id\/en\/wp-json\/wp\/v2\/posts\/20654\/revisions"}],"predecessor-version":[{"id":20656,"href":"https:\/\/fkg.ugm.ac.id\/en\/wp-json\/wp\/v2\/posts\/20654\/revisions\/20656"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fkg.ugm.ac.id\/en\/wp-json\/wp\/v2\/media\/20655"}],"wp:attachment":[{"href":"https:\/\/fkg.ugm.ac.id\/en\/wp-json\/wp\/v2\/media?parent=20654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fkg.ugm.ac.id\/en\/wp-json\/wp\/v2\/categories?post=20654"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fkg.ugm.ac.id\/en\/wp-json\/wp\/v2\/tags?post=20654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}