{"id":20488,"date":"2026-07-16T15:06:39","date_gmt":"2026-07-16T08:06:39","guid":{"rendered":"https:\/\/fkg.ugm.ac.id\/?p=20488"},"modified":"2026-07-16T15:06:41","modified_gmt":"2026-07-16T08:06:41","slug":"racun-bakteri-yang-membunuh-penjaga-imun-dari-dalam","status":"publish","type":"post","link":"https:\/\/fkg.ugm.ac.id\/en\/racun-bakteri-yang-membunuh-penjaga-imun-dari-dalam\/","title":{"rendered":"Bacterial Toxin That Kills Immune Guardians from Within"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>B lymphocytes stand at the front line of the body's defense system. They recognize threats, produce antibodies, and coordinate immune responses when infection attacks the periapical tissues of teeth. But what happens if a pathogenic bacterium can kill these immune guardians before the defense has even been established?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">This question prompted Prof. drg. Heni Susilowati, M.Kes., Ph.D., PBO, from the Department of Oral Biology, Faculty of Dentistry, Universitas Gadjah Mada, together with researchers from Universitas Kristen Duta Wacana Yogyakarta, to investigate the molecular mechanisms underlying B-lymphocyte damage following exposure to pyocyanin, a major toxin produced by Pseudomonas aeruginosa.<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">The findings, published in the Journal of Dentistry Indonesia (2015), present a concerning picture: pyocyanin can kill B lymphocytes through programmed cell death, with caspase-3 serving as the primary executioner.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>An Opportunistic Bacterium Hiding in Dental Clinics<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">Pseudomonas aeruginosa is a familiar name in the medical field. This Gram-negative bacterium is known as an opportunistic pathogen that can cause fatal infections in patients with weakened immune systems, including people living with HIV, long-term hospitalized patients, and those dependent on mechanical ventilation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">What may be surprising is that this bacterium has also been found in dental clinics. A study cited in the research identified contaminated dental unit waterlines as one potential source of its spread. Furthermore, P. aeruginosa has been isolated from bacterial colonies in periapical lesions\u2014the areas surrounding the root tips that often serve as battlegrounds for difficult-to-treat endodontic infections.<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">Failure of root canal treatment due to bacteria persisting in the pulp tissue or periapical area is a significant clinical problem. Pyocyanin, a cytotoxin produced by P. aeruginosa, is strongly suspected of contributing to the worsening of this condition through mechanisms that were not fully understood before this study.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Cells Ordered to Die<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The researchers used Raji cells, a cultured B-lymphocyte cell line, as their experimental model. The cells were exposed to different concentrations of pyocyanin (1, 5, 10, 50, and 100 \u03bcg\/mL) for 24 hours. An MTT assay was then used to measure cell viability, while morphological analysis was performed using phase-contrast microscopy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">The results were consistent and clear: the higher the pyocyanin concentration, the greater the number of B cells that died. ANOVA showed significant differences among the groups, with p = 0.000. Under the microscope, cells exposed to pyocyanin showed nuclear fragmentation, a characteristic sign of programmed cell death, or apoptosis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>\u201cPyocyanin is capable of inducing cell death in B lymphocytes. Caspase-3 may play an important role in the molecular mechanism of pyocyanin-induced cell death.\u201d<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>\u2014 Prof. drg. Heni Susilowati, M.Kes., Ph.D., PBO, et al., Journal of Dentistry Indonesia, 2015<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">To investigate the underlying molecular mechanism, the team used immunocytochemical analysis to detect the expression of active caspase-3 protein. This protein belongs to the family of executioner caspases, enzymes that execute cell death after receiving signals from initiator caspases. The results were clear: brown staining indicating active caspase-3 was visible in the cytoplasm of B cells exposed to pyocyanin, while the negative control cells remained unstained.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>When Immune Guardians Can No Longer Do Their Job<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">The implications of these findings extend beyond the laboratory. B lymphocytes are a pillar of the humoral immune system. They produce antibodies that recognize and neutralize bacterial antigens. If pyocyanin from P. aeruginosa can systematically kill these cells through the caspase-3 pathway, the bacterium is effectively disabling the host's defense system from within.<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">This mechanism may help explain why P. aeruginosa infections in periapical tissues can become persistent and difficult to control. The bacterium does not merely withstand immune attacks; it actively destroys the cells that should be leading the host's defense response.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">According to the study, caspase-3 enters the nucleus through pores opened by caspase-9 and cleaves structural proteins such as lamin A and fodrin. Lamin A cleavage causes chromatin condensation, while fodrin damage triggers the formation of apoptotic bodies, the remnants of cells undergoing programmed death.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This research opens the door to further questions: What other molecular pathways are involved? Does a similar mechanism occur in other immune cells within periapical tissues? And how can these findings be translated into more effective clinical treatment strategies for refractory endodontic infections?<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">The answers remain unknown. But we now have a clearer understanding of how P. aeruginosa begins to erode the body's defenses from within, one B cell at a time.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Source DOI: <a href=\"10.14693\/jdi.v22i2.403\">doi:10.14693\/jdi.v22i2.403<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Authors: Anny Anggraini; drg. Achmad Zam Zam Aghasy, M.Kes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Photo: Pexels<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Sel B limfosit berdiri di garis terdepan pertahanan tubuh. Ia mengenali musuh, memproduksi antibodi, dan mengordinasikan serangan imun saat infeksi menyerang jaringan periapeks gigi. Tapi bagaimana jika bakteri patogen justru bisa mematikan sel penjaga itu sebelum pertahanan terbentuk? Pertanyaan inilah yang mendorong Prof. drg. Heni Susilowati, M.Kes., Ph.D., PBO dari Departemen Biologi Oral Fakultas Kedokteran [&hellip;]<\/p>\n","protected":false},"author":615,"featured_media":20490,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[359,136],"tags":[298,307,289,291,297],"class_list":["post-20488","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artikel","category-berita-terbaru","tag-sdg-10-mengurangi-ketidaksetaraan","tag-sdg-17-kemitraan-untuk-mencapai-tujuan","tag-sdg-3-kesehatan-dan-kesejahteraan-yang-baik","tag-sdg-4-pendidikan-berkualitas","tag-sdg-9-industri-inovasi-dan-infrastruktur"],"gutentor_comment":0,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Racun Bakteri yang Membunuh Penjaga Imun dari Dalam - Fakultas Kedokteran Gigi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fkg.ugm.ac.id\/en\/racun-bakteri-yang-membunuh-penjaga-imun-dari-dalam\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Racun Bakteri yang Membunuh Penjaga Imun dari Dalam - Fakultas Kedokteran Gigi\" \/>\n<meta property=\"og:description\" content=\"Sel B limfosit berdiri di garis terdepan pertahanan tubuh. Ia mengenali musuh, memproduksi antibodi, dan mengordinasikan serangan imun saat infeksi menyerang jaringan periapeks gigi. Tapi bagaimana jika bakteri patogen justru bisa mematikan sel penjaga itu sebelum pertahanan terbentuk? Pertanyaan inilah yang mendorong Prof. drg. Heni Susilowati, M.Kes., Ph.D., PBO dari Departemen Biologi Oral Fakultas Kedokteran [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fkg.ugm.ac.id\/en\/racun-bakteri-yang-membunuh-penjaga-imun-dari-dalam\/\" \/>\n<meta property=\"og:site_name\" content=\"Fakultas Kedokteran Gigi\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/p\/Fakultas-Kedokteran-Gigi-UGM-100075927681679\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-07-16T08:06:39+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-16T08:06:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/fkg.ugm.ac.id\/wp-content\/uploads\/sites\/30\/2026\/07\/pexels-cdc-library-3992930.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1776\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"achmadzamzamaghasy\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"achmadzamzamaghasy\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/racun-bakteri-yang-membunuh-penjaga-imun-dari-dalam\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/racun-bakteri-yang-membunuh-penjaga-imun-dari-dalam\\\/\"},\"author\":{\"name\":\"achmadzamzamaghasy\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/#\\\/schema\\\/person\\\/5e527b2939dff262f173d10f32d2638a\"},\"headline\":\"Racun Bakteri yang Membunuh Penjaga Imun dari Dalam\",\"datePublished\":\"2026-07-16T08:06:39+00:00\",\"dateModified\":\"2026-07-16T08:06:41+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/racun-bakteri-yang-membunuh-penjaga-imun-dari-dalam\\\/\"},\"wordCount\":678,\"publisher\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/id\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/racun-bakteri-yang-membunuh-penjaga-imun-dari-dalam\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/wp-content\\\/uploads\\\/sites\\\/30\\\/2026\\\/07\\\/pexels-cdc-library-3992930.jpg\",\"keywords\":[\"SDG 10: Mengurangi Ketidaksetaraan\",\"SDG 17: Kemitraan untuk mencapai Tujuan\",\"SDG 3: Kesehatan dan Kesejahteraan yang Baik\",\"SDG 4: Pendidikan Berkualitas\",\"SDG 9: Industri, Inovasi dan Infrastruktur\"],\"articleSection\":[\"Artikel\",\"Berita Terbaru\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/racun-bakteri-yang-membunuh-penjaga-imun-dari-dalam\\\/\",\"url\":\"https:\\\/\\\/fkg.ugm.ac.id\\\/racun-bakteri-yang-membunuh-penjaga-imun-dari-dalam\\\/\",\"name\":\"Racun Bakteri yang Membunuh Penjaga Imun dari Dalam - 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Ia mengenali musuh, memproduksi antibodi, dan mengordinasikan serangan imun saat infeksi menyerang jaringan periapeks gigi. Tapi bagaimana jika bakteri patogen justru bisa mematikan sel penjaga itu sebelum pertahanan terbentuk? Pertanyaan inilah yang mendorong Prof. drg. 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