{"id":16781,"date":"2025-12-18T08:52:16","date_gmt":"2025-12-18T01:52:16","guid":{"rendered":"https:\/\/fkg.ugm.ac.id\/?p=16781"},"modified":"2025-12-15T09:05:24","modified_gmt":"2025-12-15T02:05:24","slug":"regenerasi-saraf-nerve-pada-trauma-mulut","status":"publish","type":"post","link":"https:\/\/fkg.ugm.ac.id\/en\/regenerasi-saraf-nerve-pada-trauma-mulut\/","title":{"rendered":"Nerve Regeneration in Oral Trauma"},"content":{"rendered":"

Trauma to the oral region, such as forceful biting, accidents, or other mechanical injuries, often results in damage to sensory nerves, particularly peripheral nerves in the jaw and lip areas. Such nerve damage may cause numbness (paresthesia), tingling sensations, or even permanent sensory loss if not properly managed. Over the past few decades, advances in biomedical research and technology have enabled nerve regeneration in the oral area through biological approaches and tissue engineering.<\/p>\n\n\n\n

Mechanisms of Nerve Regeneration in Oral Trauma<\/strong><\/h2>\n\n\n\n

Peripheral nerve regeneration following injury depends on the function of Schwann cells, growth factors, and the local microenvironment. After injury, Schwann cells form Schwann tubes that guide the growth of new axons. However, in severe or prolonged injuries, the natural regenerative process may be insufficient, making additional interventions using biomaterials and biological factors necessary.<\/p>\n\n\n\n

One promising approach involves the use of activated Platelet-Rich Plasma (PRP) combined with scaffolds (biological frameworks), such as collagen, along with additional molecules that stimulate nerve growth. This combination can create a favorable environment for axonal regeneration and sensory tissue reinnervation.<\/p>\n\n\n\n

Experimental Research: Evidence of Nerve Regeneration<\/strong><\/h2>\n\n\n\n

An experimental animal study using Wistar rats, conducted by FKG UGM student Pingky Krisna Anindra under the supervision of drg. Masykur Rahmat, Sp.BM(K), and drg. Rahardjo, SU, Sp.BM., demonstrated the regenerative potential of a combination of activated PRP, collagen sponge scaffolds, and cytidine 5\u2032-diphosphocholine (CDP-choline). The study examined regeneration of the mental nerve following crush injury using histomorphometric analysis to assess nerve fiber regrowth and cell density.<\/p>\n\n\n\n

The results showed that application of this combination stimulated faster and more significant nerve regeneration compared with the control group. The collagen structure provided physical support, PRP supplied growth factors such as PDGF and VEGF, and CDP-choline supported phospholipid metabolism in nerve membranes. Together, these components worked synergistically to accelerate reinnervation.<\/p>\n\n\n\n

Clinical Implications for Dentistry and Oral Surgery<\/strong><\/h2>\n\n\n\n
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  1. Sensory Recovery After Surgery<\/strong>
    In oral surgical procedures such as tooth extraction, implant placement, or orthognathic surgery, the risk of nerve injury is always present. Regenerative therapy based on PRP, collagen scaffolds, and CDP-choline may serve as an adjuvant strategy to accelerate nerve recovery and minimize long-term paresthesia.<\/li>\n\n\n\n
  2. Traumatic Injury Management<\/strong>
    In cases of mechanical trauma or bite injuries to the lips or jaw that damage nerves, regenerative interventions may help restore sensory function more rapidly and reduce permanent damage.<\/li>\n\n\n\n
  3. Minimally Invasive Treatment<\/strong>
    This approach offers a more biological and minimally invasive solution compared with traditional nerve surgery techniques, such as autologous nerve grafting. The use of biocompatible scaffolds and growth factors reduces donor-site morbidity and complication risks.<\/li>\n<\/ol>\n\n\n\n

    Challenges and Considerations<\/strong><\/h2>\n\n\n\n