{"id":16451,"date":"2025-10-17T14:33:42","date_gmt":"2025-10-17T07:33:42","guid":{"rendered":"https:\/\/fkg.ugm.ac.id\/?p=16451"},"modified":"2025-12-01T14:44:24","modified_gmt":"2025-12-01T07:44:24","slug":"scaffold-kolagen-untuk-penyembuhan-tulang-alveolar","status":"publish","type":"post","link":"https:\/\/fkg.ugm.ac.id\/en\/scaffold-kolagen-untuk-penyembuhan-tulang-alveolar\/","title":{"rendered":"Collagen Scaffolds for Alveolar Bone Healing"},"content":{"rendered":"

Following tooth extraction, the alveolar bone within the socket (the space formerly occupied by the tooth root) undergoes resorption and dimensional reduction, particularly on the buccal surface and in overall volume. Socket preservation aims to maintain alveolar bone dimensions to optimise subsequent implant placement or prosthetic rehabilitation. One promising approach involves the use of collagen-based scaffolds, modified and combined with biological materials such as injectable platelet-rich fibrin (i-PRF), to support alveolar bone regeneration.<\/p>\n\n\n\n

A study conducted by a student of the Faculty of Dentistry, Universitas Gadjah Mada (FKG UGM), Kent Sidharta, under the supervision of drg. Kwartarini M., Sp.Perio(K), Ph.D., and Prof. drg. Suryono, S.H., M.M., Ph.D., entitled \u201cPengaruh Kombinasi Hidrogel Kolagen\u2013Kitosan dan i-PRF Terhadap Perubahan Dimensi Tulang Alveolar pada Soket Pasca Ekstraksi Gigi Tikus Wistar,\u201d demonstrated that a collagen\u2013chitosan scaffold combined with i-PRF was able to preserve buccal bone height and increase alveolar bone volume more effectively than control groups or conventional bone grafts.<\/p>\n\n\n\n

Principles of Collagen Scaffold Design<\/strong><\/h2>\n\n\n\n

To function effectively in alveolar bone regeneration, the design of a collagen scaffold should consider the following aspects:<\/p>\n\n\n\n

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  1. Porosity and three-dimensional structure<\/strong>
    The scaffold must possess sufficiently large and interconnected pores to allow the infiltration of osteogenic cells, blood vessels, and nutrients, thereby supporting tissue regeneration.<\/li>\n\n\n\n
  2. Mechanical stability and controlled degradation<\/strong>
    The scaffold should provide adequate stability to prevent collapse during the early regenerative phase, while gradually degrading to be replaced by newly formed bone tissue.<\/li>\n\n\n\n
  3. Biological binding and growth factor release<\/strong>
    An ideal scaffold should enable the sustained release of growth factors to stimulate bone cell proliferation and differentiation.<\/li>\n\n\n\n
  4. Cellular compatibility (biocompatibility)<\/strong>
    The scaffold must support the survival, migration, and differentiation of osteoblasts and progenitor cells without inducing toxicity.<\/li>\n\n\n\n
  5. Material modification for synergistic effects<\/strong>
    The incorporation of additional materials such as chitosan, hydrogels, or i-PRF can enhance scaffold properties, including mechanical stability, growth factor delivery, and bioactivity.<\/li>\n<\/ol>\n\n\n\n

    UGM Research Findings as a Basis for Scaffold Design<\/strong><\/h2>\n\n\n\n

    Based on this research:<\/p>\n\n\n\n