{"id":16445,"date":"2025-10-15T14:19:00","date_gmt":"2025-10-15T07:19:00","guid":{"rendered":"https:\/\/fkg.ugm.ac.id\/?p=16445"},"modified":"2025-12-01T14:25:47","modified_gmt":"2025-12-01T07:25:47","slug":"peran-terapi-regeneratif-dalam-penyembuhan-jaringan-periodontal","status":"publish","type":"post","link":"https:\/\/fkg.ugm.ac.id\/en\/peran-terapi-regeneratif-dalam-penyembuhan-jaringan-periodontal\/","title":{"rendered":"The Role of Regenerative Therapy in Periodontal Tissue Healing"},"content":{"rendered":"

Conventional periodontal treatments such as scaling and root planing and surgical debridement are often insufficient to fully restore damaged periodontal structures (gingiva, periodontal ligament, cementum, and alveolar bone). Therefore, regenerative therapy approaches have emerged with the aim of stimulating natural biological processes so that periodontal tissues can be re-formed.<\/p>\n\n\n\n

One of the key components is the use of Platelet-Rich Fibrin (PRF) as a biological substrate rich in growth factors. Research conducted by a Faculty of Dentistry UGM student, Wisely Fredrian, under the supervision of drg. Hendrawati, M.Kes. and drg. Nur Rahman Ahmad Seno A., M.D.Sc., Sp.Perio., entitled \u201cThe Role of Vascular Endothelial Growth Factor Content in Platelet-Rich Fibrin on Periodontal Tissue Healing,\u201d examined how VEGF (Vascular Endothelial Growth Factor) in PRF contributes to the stages of periodontal tissue healing.<\/p>\n\n\n\n

Mechanisms of VEGF in PRF for Periodontal Regeneration<\/strong><\/h2>\n\n\n\n

Based on the research review:<\/p>\n\n\n\n

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  1. Angiogenesis in the Gingiva<\/strong>
    VEGF in PRF stimulates the formation of new blood vessels in gingival tissues, enabling the delivery of oxygen, nutrients, and progenitor cells required for regeneration.<\/li>\n\n\n\n
  2. Stimulation of Osteoblast Activity in Alveolar Bone<\/strong>
    VEGF also regulates osteoblast proliferation and differentiation, supporting new bone formation in alveolar areas affected by periodontal destruction.<\/li>\n\n\n\n
  3. Cementoblast Differentiation in Cementum<\/strong>
    In the root area, VEGF supports the growth of cementoblast cells, which play a role in forming new cementum layers.<\/li>\n\n\n\n
  4. Formation of New Periodontal Ligament Attachment<\/strong>
    Through biological signals from VEGF and other growth factors released by PRF, periodontal ligament regeneration can be promoted, strengthening the attachment between the tooth and supporting tissues.<\/li>\n<\/ol>\n\n\n\n

    The review also noted that VEGF release is higher in certain PRF variants, such as A-PRF+, compared to other variants (L-PRF, PRFM, i-PRF).<\/p>\n\n\n\n

    Advantages and Limitations of Regenerative Therapy<\/strong><\/h2>\n\n\n\n

    Advantages<\/strong><\/h3>\n\n\n\n