{"id":16161,"date":"2025-10-27T11:23:16","date_gmt":"2025-10-27T04:23:16","guid":{"rendered":"https:\/\/fkg.ugm.ac.id\/?p=16161"},"modified":"2025-11-20T09:49:36","modified_gmt":"2025-11-20T02:49:36","slug":"peran-platelet-rich-plasma-prp-dalam-penyembuhan-luka-oral","status":"publish","type":"post","link":"https:\/\/fkg.ugm.ac.id\/en\/peran-platelet-rich-plasma-prp-dalam-penyembuhan-luka-oral\/","title":{"rendered":"The Role of Platelet-Rich Plasma (PRP) in Oral Wound Healing"},"content":{"rendered":"

Oral wound healing following procedures such as tooth extraction, flap surgery, implant placement, or soft tissue surgery involves a series of biological processes, including inflammation, tissue proliferation, and remodeling. To accelerate healing, promote tissue regeneration, and reduce the risk of complications, one widely studied adjuvant therapy is Platelet-Rich Plasma (PRP). PRP contains a high concentration of platelets that release growth factors\u2014such as PDGF, TGF-\u03b2, and VEGF\u2014which stimulate angiogenesis, cell proliferation, and tissue remodeling.<\/p>\n\n\n\n

PRP formulations are often combined with scaffolds (e.g., hydrogels, collagen, chitosan) to improve their physical and rheological properties, making application more practical, enhancing retention at the wound site, and enabling more controlled release of growth factors.<\/p>\n\n\n\n

Related Research<\/strong><\/h2>\n\n\n\n

A study conducted at Universitas Gadjah Mada (UGM) by a Faculty of Dentistry student, Tutut Prabantari A, under the supervision of drg. Kwartarini Murdiastuti, Sp.Perio(K)., Ph.D., and drg. Sri Pramestri Lastianny, M.S., Sp.Perio(K), entitled \u201cPengaruh berbagai formulasi hidrogel kolagen kitosan pada Platelet-Rich Plasma terhadap pH, viskositas, dan kelarutan,\u201d investigated how scaffold formulations\u2014specifically collagen\u2013chitosan hydrogel\u2014affect the physical properties of PRP.<\/p>\n\n\n\n

The study assessed key physical characteristics of PRP formulated with collagen\u2013chitosan hydrogel, namely pH (acidity level), viscosity (degree of thickness and homogeneity), and solubility (the ability of components to dissolve or disperse within the scaffold). These parameters are critical because they influence PRP stability, adhesion to the wound site, growth factor release, and ease of clinical application.<\/p>\n\n\n\n

Clinical Implications of PRP in Oral Wound Healing<\/strong><\/h2>\n\n\n\n

Based on theoretical considerations and findings related to the physical properties of PRP\u2013scaffold formulations:<\/p>\n\n\n\n

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  1. Effect of pH<\/strong>\n